Residents from surrounding areas have described how trees and debris from a collapsed mountainside buried parts of the community, leaving it isolated.
Footage from the scene shows locals pulling bodies from beneath rubble and trees as they traverse the terrain, covered by giant boulders and uprooted trees.
A resident from a nearby village said that when he arrived at the scene of the landslide, “there was no houses [left]”.
Speaking to Australian broadcaster ABC, Dominic Lau said it was all “just flat with soil”.
“There was nothing, just rocks and soil… there were no people and there were no houses to see,” Mr Lau added.
Enga’s governor Peter Ipatas told AFP as many as “six villages” had been affected by the landslide, which he described as an “unprecedented natural disaster”.
Enga is more than 600km by road from the country’s capital, Port Moresby.
Papua New Guinea’s Red Cross Society earlier said an emergency response team made up of officials from the provincial governor’s office, police, defense forces, and local NGOs had been deployed to the site.
Speaking on Friday, Papua New Guinea’s Prime Minister James Marape said authorities were responding to the disaster.
He said the government is working with local officials to provide “relief work, recovery of bodies, and reconstruction of infrastructure”.