He warned Israelis that “challenging days lie ahead… we have heard threats from all sides. We are prepared for any scenario”.
Earlier, Pentagon spokesperson Sabrina Singh said the US did not believe escalation was inevitable.
“I think we are being very direct in our messaging that certainly we don’t want to see heightened tensions and we do believe there is an off-ramp here and that is that ceasefire deal,” Singh said.
An Israeli delegation will travel to Cairo in coming days for negotiations to reach a Gaza ceasefire and hostage release deal, Mr Netanyahu said on Friday.
Hamas sparked the war with its 7 October attack on Israel, which killed 1,200 people. Israel responded with an ongoing military operation in Gaza that has killed almost 40,000 people, according to the Hamas-run health ministry.