Weather permitting, it should spend 20 days above the wreck, which lies in 3,800m (12,500ft) of water.
It will be a poignant few weeks for all involved.
One of the five who died on the OceanGate sub was Frenchman Paul-Henri (“PH”) Nargeolet. He was the director of research at RMS Titanic Inc. and was due to lead this expedition.
A plaque will be laid on the seabed in his honor.
“It’s tough but the thing about exploration is that there’s an urge and a drive to keep going. And we’re doing that because of that passion PH had for continuous exploration,” explained friend and historian Rory Golden, who will be “chief morale officer” of Dino Chouest.
There can be few people on Earth who don’t know the story of the supposedly unsinkable Titanic and how it was holed by an iceberg, east of Canada, on the night of 15 April 1912.
There are countless books, movies and documentaries about the event.
But although the wreck site has been the target of repeated study since its discovery in 1985, there still isn’t what could be described as a definitive map.
And while the bow and stern sections of the broken ship are reasonably well understood, there are extensive areas of the surrounding debris field that have received only cursory inspection.